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That does not make them bad

Hoek J, Ball J, Nip J, et al

Smoking and microbiome in oral, airway, gut and some systemic diseases

Goblet cell hyperplasia leads to hypersecretion of mucus by goblet cell, and less mucus clearance leads to airway inflammation, structural changes, and obstruction in airways mainly luminal obstruction of small airways, epithelial remodeling, accelerated lung function decline, and alteration of airway surface tension predisposing to collapse of patients with chronic bronchitis