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Alzheimers disease (AD), the most common form of dementia worldwide 270,271 , is characterized at the molecular level by the accumulation of A plaques, tau neurofibrillary tangles (NFTs), declined NAD + levels, mitochondrial stress, and impaired mitophagy, occurring first in the medial temporal lobe and eventually spreading to temporal and parietal cortices, and cortex 112,242,243,270,271,272

in the first half of 2024

Key cuproptosis molecular changes in cardiovascular diseases Copper homeostasis is critically involved in the pathophysiology of myocardial I/R injury, with both deficiency and excess exacerbating damage through distinct mechanisms [158]

That asymmetry does not make the comparison worthless

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