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To date, only a single patient has been identified with a suspected deficiency in dipeptidase activity (Njalsson and Norgren, 2005

On this basis, the diagnostic criteria and treatment guidelines of the HRS were revised (Angeli et al., 2015)

Class Tripeptide thiol Also known as L-Glutathione (reduced) GSH -Glutamylcysteinylglycine Molecular formula C10H17N3O6S Molar mass 307.32 g/mol CAS number 70-18-8 PubChem CID 124886 UNII GAN16C9B8O Appearance White to off-white powder Storage Store lyophilized at -20 C, protected from light

Mazta Farma, Indonesia)comprising L-glutathione (fermentation), ascorbic acid, ALA, and zinc (as zinc aspartate)as a skin-lightening agent in healthy Indonesian women, measured using a facial analysis system for assessment every four weeks over a 12-week period

Acknowledgements We thank CHA Bio Complex for excellent guidance and assistance with the performed mouse experiments