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Equally unresolved is how redox thresholds are established namely, when GSH-mediated buffering shifts from protective to permissive for cell death, and how changes in NADPH availability, metal speciation, or mitochondrial dependence reprogram this balance

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Taking into account these limitations, one of the more informative studies was performed by Miele et al

Bioavailability refers to the proportion of a nutrient that enters the circulation when introduced into the body and is so able to have an active effect