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Further studies of the role of c-MET/HGF signalling in SCLC will help to improve the understanding of the mechanism of invasion and metastasis in this aggressive disease

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studied IC/BPS patients with Hunner lesions and abnormal bladder biopsy results (including histopathologic findings of inflammatory infiltrates, granulation tissue, overexpression of mast cells, and/or intrafascicular fibrotic changes), also called ESSIC type 3C disease ( Box 35.2 ), and compared them to IC/BPS patients with normal cystoscopy and biopsy results

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