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On the medical side, there were concerns about heart attacks and stroke on varenicline, but the FDA was reassured after a large randomized controlled trial did not find a statistical increase in these events (Benowitz NL et al, JAMA Intern Med 2018;178(5):622631)

Interestingly, there was no correlation between the levels of these two proteins (R = 0.046) (Table 2, Supplementary Table S1)

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