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The number and capacity of our mitochondria decrease as we age, this reduces health and longevity

Furthermore, evidence indicates that NRF2 can transcriptionally upregulate CHAC1, as observed in ferroptosis-resistant melanoma cells where CHAC1 induction occurs independently of ER stress ( de novo GSH synthesis (Kre et al., 2023)

doi: 10.1186/s40104-022-00812-1 20

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