As a multi-component botanical agent, ginger synergistically combines the protective effects of its constituents to maximize anti-ferroptotic activity, prevent VSMC phenotypic switching, and thereby mitigate vascular remodeling
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Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration
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Abraham K, Penczynski K, Monien BH et al (2023) Risks of misinterpretation of biomarker measurements in spot urine adjusted for creatinine a problem especially for studies comparing plant based with omnivorous diets
