Cycling NAC prevents building a tolerance, which can have effects on your mood, whereas cycling caffeine can keep you from developing a dependency on it.79 Whether you choose to cycle because of caffeine may depend on your own consumption habits and the amount of caffeine present in the nootropic
Mouse model of B12 deficiency Female C57BL/6 and SCID mice were fed with a diet similar to control group normal diet (Teklad 2014S, ENVIGO), but with no added B12 and with 5% Pectin (Tekland custom diet TD.170206, ENVIGO)
doi: 10.1039/C9RA03848E 143 XingF.HuQ.QinY.XuJ.ZhangB.YuX.et al
While supplementation can be beneficial, factors such as diet, sleep, lifestyle and overall health also play an important role in maintaining healthy glutathione levels
But in either case, it is always worth analyzing your purifications to know if there is any room for further optimization