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BMC Microbiology 2020;20(87):1-9

As Phase I trials evolve to include more personalized and targeted therapies, PRO data will likely become integral in shaping precision dosing and optimizing patient experiences

However, obestatin was shown to stimulate POMC expression and ACTH release in vitro and in vivo , and in this study the authors found GPR39 expression in pituitary tissue and primary pituitary cell cultures, contrary to the above-mentioned studies