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Transcriptional regulation by Nrf2

S.ElikaeeS.RajabS.SalamL.et al (2022)

Beyond these environmental factors, a number of genetic factors link impaired mitochondrial biology to the pathogenesis of ALS [54]

In vivo studies in iron-deficient mice confirm this: erythrocytes exhibit increased PS exposure, reduced glutathione (GSH) levels, and accelerated clearance, with these defects reversed by iron repletion (Kempe et al., 2006)

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