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An accurate diagnosis requires imaging that specifically evaluates both segments, since the overlapping nerve pathways can make the two conditions difficult to distinguish on symptoms alone

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10.1146/annurev.pa.25.040185.003435 Ann Rev Pharmacol Toxicol

For instance, 3D structure-based nano-in-microparticles synthesized using polysaccharides such as maltodextrin or dextran, amino acids, and doped with copper oxide (CuO) or zinc oxide (ZnO) NPs are used for skin repair and to prevent bacterial infection by overcoming colonization