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Conclusion Cigarette smoking might seem classy and elegant, but it comes with serious health risks

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The E-ACES system detection limit (LOD) for nicotine was 0.088 g/puff and for aldehydes it was 0.0160.244 g/puff (formaldehyde and acetaldehyde were 0.016 and 0.032 g/puff, respectively) using a 5-puff aerosol collection (4 s puff duration and 30 s interval) and 6 ml extraction

Kenkel, D S, A D Mathios, and H Wang (2020), E-Cigarettes and Respiratory Disease: A Replication, Extension, and Future Directions, NBER Working Paper 27507

Therefore, it is crucial to establish a clear and definitive diagnosis