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Mendelian randomization analysis (UK Biobank, n = 321,412) revealed that metformin promoted healthy aging through its targets glycerol-3-phosphate dehydrogenase 1 (GPD1) and AMPK2

& Rawlings, N

trypsin-EDTA (0.25%) and L-Glutamine-Penicillin-Streptomycin solution were obtained from Wuhan Servicebio Technology Co., Ltd

Consistently, we found that the expression of xCT in the kidney was significantly downregulated induced by FA injection, which was closely related to the decrease in GSH levels

Correspondingly, treatment with exogenous GSH and LPS was found to delay apoptosis and reduce the level of the pro-apoptotic protein caspase-3 (169)