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Despite the promising therapeutic potential of azelaic acid in melasma, however due to limited water solubility and poor skin permeability, its conventional topical formulations have been fabricated in higher doses (10%20%) to achieve the desired clinical outcome (Sieber and Hegel, 2014

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2010 Feb;61(1):67-72

The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms

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