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These prodrugs remain intact and inactive when circulating in plasma, that is, add profragments preferentially cut by enzymes enriched in the tumor (such as histone deacetylase (HDAC) or cathepsin), and then selectively release DON in the target tissue, thereby reducing the dose and increasing the therapeutic index

Hashimotos, an autoimmune cause of hypothyroidism, is linked to low selenium.[ref] Related article: Genetics and thyroid function

Proper storage is essential to preserve stability, integrity, and research reliability

MGF (Mechano Growth Factor) supports muscle repair by activating satellite cells and promoting tissue regeneration, speeding up recovery after intense physical activity

doi: 10.20517/cdr.2024.127 268 WangJChenTGaoF