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The area located at the C-terminus is hydrophilic due to the +2 protons, responsible for the lytic activity, for a total of +6 charges at physiological Ph (Bava et al., 2023)

ncbi.nlm.nih.gov/pmc/articles/PMC3206257 Sikiric P, et al

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Uversky, 1994)

Epithalon was first synthesized from research into pineal gland peptides and has been studied since the 1980s, when Vladimir Khavinson's work on pineal extracts identified the tetrapeptide