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Induction of a senescence-like phenotype in cultured human fetal microglia during HIV-1 infection
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and K99-DC021195 to C.N.M.), National Science Foundation (NeuroNex UTA20-000889 to A.Y.T
Given the robustness of this mitochondrial response, the multifaceted nature of PGC1 regulation in cells and a modest rescue at best by mTORC1 inhibition, we suspect that there is a degree of functional redundancy built into this metabolic plasticity system that can contribute to such an adaptive response, and complete inhibition of this system will prove difficult
However, more human studies are needed to assert that choline supplementation during pregnancy improves cognitive performance in the offspring or that choline supplementation helps prevent cognitive decline in older people
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