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Developed in the 1970s, it remains the most-ordered IV in clinics worldwide

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For example, research on skeletal muscle satellite cells demonstrated that He-Ne laser (632.8 nm) upregulates the anti-apoptotic protein Bcl-2 and downregulates the pro-apoptotic protein Bax, thereby stabilizing mitochondrial membrane potential, reducing cytochrome c release, and ultimately inhibiting caspase-3 activation ( 3 Concept and practice for intra-articular PBMT of KOA 3.1 Fundamental solutions for intra-articular energy delivery In recent years, the modification of acupuncture needles into multifunctional, intelligent drug and energy delivery vehicles has emerged as a rapidly developing research direction in KOA treatment