l-carnitine ejection fraction Modeling Heart Failure With Preserved Using Human Induced Pluripotent Stem Cell–Derived Cardiac Organoids Intestinal microbiota metabolism of l-carnitine,

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However, low-dose IPA (20 mg/kg) administration demonstrated marginal attenuation of disease phenotypes, showing only modest mitigation in pathological indices, mucosal barrier integrity and inflammatory markers that failed to reach statistical significance compared to vehicle-treated controls (Fig

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Furthermore, the human AD gut microbiota promotes an intestinal inflammatory state by lowering P-glycoprotein expression and slightly elevating MRP2 protein levels in cultured intestinal epithelial cells, thus modulating inflammatory responses against commensals [329]

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