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Moreover, a lower level of glycine was observed in liver and colon tissues, which indicates that the gut microbiota regulates glutathione metabolism, not only in the small intestine but also in the liver and the colon

3a) Consistent with a deleterious role for free iron in ASCVD, ApoE-/- mice exposed to chronic iron overload displayed exacerbated atherosclerosis likely secondary to VEC damage or death, which was attenuated by dietary iron restriction or iron chelation 62,63

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