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Since IGF-1 encourages cell division, it could theoretically stimulate the growth of abnormal or precancerous cells

[PubMed: 71835] 151

Dose escalation identified dose-limiting toxicitiesprimarily thrombocytopenia and neutropeniawith the maximum tolerated dose established at 675 mg/m weekly

Inflammation is caused by excessive pressure or rubbing over the elbow causing the bursa to become inflamed

Eric Topol of Scripps Research Translational Institute was more direct: "These peptides have no data to support their safety and efficacy." The clinical proponents argue that the FDA's safety concerns immunogenicity risk, impurity risk, organ toxicity are theoretically valid but speculative in practice