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44 , 45 In fact, oxidative stress plays a vital role in the pathology of several neurological diseases including Alzheimer disease, 46 Parkinsons disease, 47 Down syndrome, 48 schizophrenia, 49 major depressive disorder, 50 anxiety disorders such as panic disorder, 51 and obsessive-compulsive disorder

doi: 10.1186/s12977-024-00640-3 28 MohagheghiMEftekharianMMTaheriMAlikhaniMY

Conversely, this same property makes result interpretation extrapolable to physiological biology trickier: in vivo, IGFBPs are not simple "plugs" but sophisticated regulators of IGF homeostasis

Cell Commun Signal 22:7 McElwee MK, Song MO, Freedman JH (2009) Copper activation of NF-kappaB signaling in HepG2 cells

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