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Excessive melanin production leads to hyperpigmentation, such as melasma and dark spots

The clearest distinction between them is how long each remains active

Early and smaller studies suggested effects on fat metabolism and body fat distribution, but larger obesity trials did not show a robust, clinically meaningful weight loss outcome on their own

Among vasculogenic ED patients, traditional ED treatments such as selective PDE5 inhibitors, which act on the penile musculature via the NO system, often fail to elicit long-term therapeutic outcomes in subjects with severe cardiovascular and metabolic disease