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According to one comprehensive analysis, knee OA has been sharply on the rise over the past three decades, with over 3 million cases reported world-wide in 2021, compared to only 1.4 million in 1990

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Choline deficiency can impair fat export, leading to hepatic steatosis, though dietary choline intake is typically adequate in most individuals

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Drug Interactions Other Medications and Supplements Lipotropic agents and high-dose B12 may interact with certain prescription drugs (e.g., levodopa, methotrexate) or other supplements