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Beyond its key role in skeletal homeostasis, several recent studies suggest extra-skeletal effects, such as a role as an immunomodulator in both adaptive and innate immune responses [102]

Collectively, these findings suggest that MC1R signaling may participate in broader regulatory roles related to cellular homeostasis and stress resilience

Nevertheless, hemeHPX endocytosis also occurs in mouse embryonic fibroblast LRP1 / PEA 13 cells

(PMID: 34827486) and the broader systematic review by Ho and Nation (PMID: 29733881) provide some supporting evidence from outside the affected research group