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[1] One trial did find that oral supplementation of glutathione did have an effect on increasing your body's level of glutathione, indicating that at least some of it does still get through your system to take effect

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Right now, only a few products offer this kind of way to take glutathione

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Lifehacks: Chemotherapy and cancer: Changes in the ABCC11 gene may impact your reaction to a type of chemotherapy drug called fluorouracil.[ref] Talk with your doctor if you have concerns here