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Initially, nano-antimicrobial agents faced the challenge of the burst effect: the early release of large amounts of antimicrobial agents caused local drug concentrations to rise, leading to significant cellular toxicity and a sharp decline in antimicrobial efficacy later on ( Additionally, concerns arose regarding the accumulation of metal nanoparticles in the body, their potential to induce inflammation, and the risk of breaching the blood-brain barrier (Wang et al., 2023

Additionally, a non-invasive mild TBI model was developed in adult zebrafish using a laser to induce damage to neural tissue (119)

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Specific Symptoms of Testosterone Deficiency (TD) These symptoms are more directly linked to TD: Reduced Sex Drive : A noticeable decrease in sexual desire or libido

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