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It has been well shown that circulating markers of oxidative stress are abnormal in women with PCOS with an average increase of 23% of blood fasting homocysteine (Hcy) [2]

A rather simple but very effective method of removing dominant epitopes to enhance responses to conserved subdominant epitopes involved the removal of the S1 portion of spike containing the RBD and then the administration of a vaccine with only S2 as a DNA vaccine or protein [73] (Table 2)

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