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Drugs that are administered orally and are absorbed across the intestinal mucosa must first pass through the liver via the portal circulation before being distributed to the rest of the body

The preservation of endothelial function, as seen in isolated rat hearts treated with verapamil (an L-type calcium antagonist used in the treatment of hypertension and stable angina), correlates with improved coronary flow, functional recovery, and reduced histopathological markers in ECs [123]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 148.Gugliandolo A., Bramanti P., Mazzon E

Kornblau SM, Thall P, Walterscheid M, Estrov Z, Keating M, Patel S, Kantarjian H, Estey E, Andreeff M