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AlZaim, I., de Rooij, L., Sheikh, B

Marcel Monnier and Lucien Hsli at Basel had reported, in cross-circulation experiments dating back to the 1960s, that low-frequency electrical stimulation of the intralaminar thalamic nuclei in donor rabbits produced a humoral factor that, when transferred to awake recipient rabbits via dialysed cerebral venous blood, induced an EEG pattern resembling slow-wave sleep

This in itself can produce more oxidative stress and can lead to inflammation and even thyroid autoimmunity

Additionally, pro-apoptotic proteins can be activated and anti-apoptotic proteins can be suppressed by calcitriol/VDR signaling, which may also reduce tumor-associated inflammation by suppressing the cyclooxygenase-2, prostaglandin, and NF-kB pathways

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