The structures of some isocereulides differed from that of cereulide by substitution of L- O -Val by L- O -Leu (isocereulide A), L-Val by L-Ala (isocereulide D), D-Ala by D-Ser (isocereulide C) and D- O -Leu by D- O -Val (isocereulide B), thus indicating a relaxed substrate specificity of the A domains and an inefficient proof reading by CesT 18
These differences highlight the interplay between genetic background and environmental exposure
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Brain Behav Immun 115:312 Osimo EF, Pillinger T, Rodriguez IM et al (2020) Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls