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Lead (Pb)-induced oxidative stress and toxicity reduced the expression of selenoprotein mRNAs, and the effect was mitigated by selenium supplementation 129

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reported that Asp and Asn in colon cancer cell lines could inhibit their activities by binding to LKB1 (encoding filament, threonine kinase, and direct phosphorylation of protein products to activate AMPK), thus inhibiting AMPK-mediated p53 activation

Liao Z, Zhang Z, Jin J, Ajani JA, Swisher SG , Stevens CW, Ho L, Smythe R, Vaporciyan AA, Putnam JB Jr, Walsh GL, Roth JA, Yao JC, Allen PK, Cox JD, Komaki R

Thus, arginase 1 inhibitors can exert a double-strike, promoting antitumor immunity and dysregulating important metabolic pathways for tumor and CAFs cells biology/function