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Resveratrol suppresses interleukin-1-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis

While hot flashes are not listed as a recognized adverse effect in FDA prescribing information, some patients report experiencing these symptoms during treatment

[DOI] [PMC free article] [PubMed] [Google Scholar] Nohria A, Prsic A, Liu P-Y, Okamoto R, Creager MA, Selwyn A, Liao JK, Ganz P, 2009

Kalogjera L, Krezic I, Smoday IM, Vranes H, Zizek H, Yago H, Oroz K, Vukovic V, Kavelj I, Novosel L, Zubcic S, Barisic I, Beketic Oreskovic L, Strbe S, Sever M, Sjekavica I, Skrtic A, Boban Blagaic A, Seiwerth S, Sikiric P

The list includes cytochrome c oxidase (the terminal electron-transport-chain enzyme), Cu/Zn superoxide dismutase (an antioxidant enzyme), lysyl oxidase (which cross-links collagen and elastin in extracellular matrix), tyrosinase (in melanin synthesis), dopamine beta-hydroxylase (in neurotransmitter synthesis), and others