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Acknowledgements This research was supported by the National Key R&D Program of China (2018YFC1313304, 2018YFC1313300), National Natural Science Foundation of China (81930065, 81871951), Natural Science Foundation of Guangdong Province (2019A1515010233, 2018B030306049), Pearl River S&T Nova Program of Guangzhou (201806010002), and CAMS Innovation Fund for Medical Sciences (CIFMS) (2019-I2M-5-036)
A meta-analysis of nine randomised trials in 591 women with PCOS found significant reductions in HOMA-IR, total cholesterol, and triglycerides, with no clear effect on luteinising hormone, total testosterone, or sex hormone binding globulin
In addition, genome editing is an approach in which a specific target gene can be engineered by adding, deleting or replacing the nucleotides
Choline supplementation is therefore being investigated as a potential homocysteine-lowering strategy
doi: 10.1016/s0014-5793(98)00410-4
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