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Its stability in the gut is one of its most unique properties, suggesting a resilience that many other peptides lack

PMID 12749025

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Safety: what we know, what we dont What clinical trial safety reviews suggest The clinical safety review literature reports several reassuring signals: No meaningful increase in IGF-1 in monitored long-term studies (jofem.org) No clear negative effect on carbohydrate metabolism in testing described (contrast with full hGH) (jofem.org) No clear immunogenicity signal (e.g., anti-AOD antibodies) in the subset assessed in those trials (jofem.org) The major limitation: long-term real-world certainty is thin The problem with many peptides is not that everything is dangerousits that the certainty level is often lower than patients assume

For instance, deficiencies in both could cause fatigue, but nerve pain was unique to B12, and bone pain was associated with a D deficiency