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Second, brain-mediated autonomic effects are exactly the kind of physiology that is subject to adaptation and counter-regulation over time, which is the mechanistic basis for the tachyphylaxis concern examined below

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The first group consists of compounds containing only the phenothiazine nucleus (phenothiazine and 2-chlorophenothiazine)

Subsequent interest in AOD-9604 has been limited to niche research areas, particularly osteoarthritis, where intra-articular injection might bypass systemic bioavailability limitations

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