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6.1.2 WILLOW study (phase II clinical trial) 6.1.2.1 Study design and population The WILLOW study represented a pivotal Phase II clinical trial of brensocatib in bronchiectasis patients ( The study recruited 416 patients total, with 256 patients meeting inclusion criteria completing randomization, allocated to placebo group (87 patients), 10 mg brensocatib group (82 patients), and 25 mg brensocatib group (87 patients)