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There are, however, two studies that we can call on: Pentadecapeptide BPC 157 Interactions with Adrenergic and Dopaminergic Systems in Mucosal Protection in Stress (link) This study wasnt designed to find the comparison between two administration methods, but it did look at how different systems of the body would affect these two methods

doi:10.1073/pnas.0914399107

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Hydration is configurable: run a 2L bladder in the rear for efforts over 90 minutes, or drop in dual 500ml soft flasks up front when you want faster refills on race day