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investigated the structural and functional effects of PEGylation on the antimicrobial peptide LyeTx I-b, demonstrating that the PEGylated derivative, LyeTx I-bPEG, exhibited enhanced resistance to proteolytic enzymes such as trypsin while maintaining antimicrobial activity and reducing cytotoxicity (Fig

128 In an immunohistochemical study, Volk and Loscher 129 demonstrated that rats resistant to AED therapy had higher levels of Pgp expression in brain capillary ECs than did control animals

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