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It must also be noted that the significant effects we found were only small (see Table 2)

These findings provide a robust methodological platform for tobacco research as well as mechanistic insights into how prolonged smoke exposure promotes epithelial adaptation, revealing NRF2-dependent resilience as a crucial early marker in smoking-related lung cancer development

Finally, despite comprising only 3.5% of global areas, Extremely high densitie, i.e., hotspots, were identified across several countries, underscoring the global scale of this issue and facilitating the identification of global hotspots

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