Current CVD research reveals a critical knowledge gap: although preclinical studies robustly demonstrate that ferroptosis inhibition attenuates tissue injury, the molecular pathways governing its activation are highly context dependent, and its definitive contribution to human disease progression remains incompletely defined
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Decreased availability of glutamate limits anaplerosis of the TCA cycle, resulting in low mitochondrial respiration, and nitrogen source, resulting in the high dependency on exogenous non-essential amino acids
Mushrooms are the leading dietary source of the longevity vitamin ergothioneine
