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10.1016/j.canlet.2013.08.031 29

We reported previously that silencing LDHB in KRAS -mutant lung cancer cell lines significantly reduced the expression of SLC7A11 11 , which is required for oncogenic RAS transformation and encodes a plasma membrane-localized cystine/glutamate antiporter that provides cysteine for GSH synthesis 22,23

This is the most critical step

The infiltrated substances and activated immune cells amplify ROS production, worsening BBB damage and perpetuating the pathological cascade seen in neurodegenerative diseases [172,198,199]