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First, the bidirectional regulatory loop between ferroptosis and the Atau axis in the AD microenvironment has not been resolved

This hypothesis was further supported when similar findings were obtained with ferrous iron treatment

The mutations include deletion, missense, heterozygous, and exon deletions, resulting in blood Mn concentrations 520 times above the normal range (Winslow et al., 2020

3), with a lower RR and MEV than thiamine (Table 1), resulting from the heterobicyclic structure that comprises 2-oxohexahydro-1 H -thieno[3,4-d]imidazole that has a valeric acid substituent appended to the tetrahydrothiophene ring which limits the odds of flexibility inside the active site of M pro and that was affirmed by the recorded interactions (Table 1) compared with the thiamine vitamin