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Due to the lack of standard and practical biomarkers, it is impossible to verify whether a drug truly induces ICD in patients, or to determine the optimal biological dose, leading to blindly designed clinical trials

27, 28, 29, 30, 31 Most importantly, prophylactic administration of antioxidants can ameliorate behavioral deficits in adulthood in animal models

A meta-analysis of high dose, intermittent vitamin D supplementation among older adults