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More than 80 percent of adult smokers started before the age of 19, according to the 2012 Surgeon Generals Report

Due to the convenient availability of tobacco, cigarettes and other smoking devices, its a habit that forms easily but is just as hard to let go of

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Consistent with these findings, adoptive transfer studies have demonstrated that cigarette smoke exposure selectively enhances the proinflammatory properties of Th17 cells and the immunosuppressive activity of Treg cells through a GPR15-dependent mechanism, underscoring GPR15 as a central regulator of divergent T-cellmediated immune responses to environmental factors in colitis