Acetyl-L-carnitine (ALC) is the most important derivative of carnitine and occurs naturally in the body
Hence, to date, no suitable compound has been identified to inhibit the plasma membrane glutamine transporter SLC1A5 with excellent sensitivity and specificity
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In this study, as amino acid precursors could be fed to improve concentrations of intracellular free l-cysteine, we resorted to overexpression of GK instead of loss-of-function mutations in GPR for accumulation of -glutamyl phosphate to strengthen the redirection of -glutamyl phosphate to GSH synthesis

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