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Despite the concentrated research on mammals, the current sleep definition lacks an all-inclusive explanation to cover its evolutionary-conserved role, lending support to the hypothesis that sleep serves a fundamental need, and the best way to define sleep would be to identify this need

Published rodent pharmacokinetic data with rigorous plasma quantification are limited, and no human bioavailability study has been published in the peer-reviewed literature as of this writing

These cells can arise from various sources, including the transdifferentiation of resident fibroblasts (fibroblast-to-myofibroblast transition, FMT), epithelial cells (epithelial-to-mesenchymal transition, EMT), or endothelial cells (endothelial-to-mesenchymal transition, EndMT) [86]

10.3390/ijms26136439 24 DelkhoshA.DelashoubM.TehraniA