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The San-Huang-Yi-Shen capsule (SHYS) significantly reduces Fe 2 levels while enhancing SLC7A11, GPX4, and GSH/GSSG levels, providing renal protection in diabetic nephropathy models [98]

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Notably, Nrf2/HO-1 inhibits the overexpression of the key inflammatory mediator cyclooxygenase-2 (COX-2), resulting in an anti-inflammatory effect

The origins of spatial omics trace back to early tissue section analyses, which primarily relied on microscopy and immunohistochemistry