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Besides, inhibition of HDACs and histone hyperacetylation, the neuroprotective effect of HDACi may also involve multiple mechanisms of action, involving activation of the kinase pathway by extrinsic signals (Hao, 2004) the suppression of pro-apoptotic factors (Kim et al., 2007) or microglialmediated inflammation (Peng et al., 2005), as reported earlier for valproic acid

M.ShahmohammadiA.MehrabiZ.FallahS.BaluchnejadmojaradT.et al (2022)

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And the dose-dependent effects were clear: 4 mg, 8 mg, and 12 mg doses all produced escalating weight loss, with the highest dose delivering the most dramatic results

B vitamins in stroke prevention: time to reconsider